A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic.
نویسندگان
چکیده
A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 31 شماره
صفحات -
تاریخ انتشار 2012